A case of hypotension and heart rate changes on rechallenge with a low dose of clozapine with no apparent secondary cause

Harshini, M. L.; Fernando, A. I. W.; Abayawickrama, H. M. T. S.; Ikram, M. I. N.; Rajapakse, S.; Hapangama, A.

doi:10.4038/sljpsyc.v13i2.8350

Journals › Sri Lanka Journal of Psychiatry

A case of hypotension and heart rate changes on rechallenge with a low dose of clozapine with no apparent secondary cause

M. L. Harshini iD, A. I. W. Fernando, H. M. T. S. Abayawickrama, M. I. N. Ikram, S. Rajapakse, A. Hapangama

Sri Lanka Journal of Psychiatry 13(2): 52–54 · 2022

https://doi.org/10.4038/sljpsyc.v13i2.8350

Abstract

Clozapine is known to cause innocuous as well as severe and or fatal cardiovascular side effects. These side effects are commonly reported at the initiation of clozapine therapy. We report a patient who was stable on clozapine for several years but in whom we had to withhold clozapine for medical reasons and subsequently developed significant hypotension and heart rate changes when rechallenged with a small dose of clozapine.

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