Disseminated Fusarium infection in an immunocompromised patient Successful outcome with combined antifungal therapy

Welagedara, P.G.R.U.M.; Somawardana, U. A. B. P.; Madarasinga, N. P.; Manchanayaka, M. A. N.; Wijesinghe, C. N.; Premathilaka, G. D. I.; Welagedara, P. G. R. I. S.; Sigera, L. S. M.; Gunasekera, S. P.; Jayasekera, P. I.

doi:10.4038/sljid.v12i2.8477

Journals › Sri Lankan Journal of Infectious Diseases

Disseminated Fusarium infection in an immunocompromised patient Successful outcome with combined antifungal therapy

P.G.R.U.M. Welagedara iD, U. A. B. P. Somawardana iD, N. P. Madarasinga, M. A. N. Manchanayaka, C. N. Wijesinghe, G. D. I. Premathilaka, P. G. R. I. S. Welagedara iD, L. S. M. Sigera, S. P. Gunasekera, P. I. Jayasekera

Sri Lankan Journal of Infectious Diseases 12(2) · 2022

https://doi.org/10.4038/sljid.v12i2.8477

Abstract

Fusarium species are plant pathogens which exist ubiquitously in the environment. While they can cause superficial and subcutaneous infections in healthy individuals, they can give rise to deep and disseminated infections in immunocompromised patients, particularly in patients with haematological malignancies with a high risk of mortality. This case describes a young male diagnosed with B cell Acute Lymphoblastic Leukaemia (B-ALL) who developed disseminated Fusarium infection with febrile neutropenia following induction chemotherapy. Necrotic skin lesions led to the diagnosis in this patient. Though the patient had a clinical recurrence of infection due to inadequate treatment initially, he was finally completely cured with combined antifungal therapy using amphotericin B and voriconazole.

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