Journals › Sri Lankan Journal of Infectious Diseases
Comparative Evaluation of Typhidot IgM and Widal Tests for Typhoid Fever Diagnosis in a Tertiary Care Setting in Delhi, India
Sri Lankan Journal of Infectious Diseases 15(1) · 2025
https://doi.org/10.4038/sljid.v15i1.8750
Abstract
Background: Typhoid fever remains a significant public health challenge in developing countries. Accurate and timely diagnosis is crucial for effective management and control. This study aimed to compare the diagnostic performance of Typhidot IgM and Widal tests in a clinical setting in Delhi, India.Methods: We conducted a retrospective analysis of data from patients with suspected typhoid fever at G.B. Pant Hospital from January 2024 to August 2024. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and receiver operating characteristic (ROC) analysis were performed for both tests, using blood culture as the gold standard where available. In the absence of blood culture results, diagnosis was based on clinical criteria and response to treatment.Results: Of the 412 patients included, 137 (33.3%) were confirmed positive for typhoid fever. Typhidot IgM demonstrated higher sensitivity (91.2% vs. 69.3%, p
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