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Ciprofloxacin resistant Escherichia coli : characterisation of phylogeny, virulence and antimicrobial resistance of isolates from extra intestinal infections of humans and chickens in selected geographical locations of Sri Lanka

G. A. D. K. K. Gunathilaka iD, W. A. P. M. Dewasmika iD, D. R. A. Dissanayake iD, B. N. Dissanayake iD, M. A. R. Priyantha iD, D. V. P. Prasada

Sri Lankan Journal of Infectious Diseases 15(2) · 2025

https://doi.org/10.4038/sljid.v15i2.8807

Abstract

Introduction: Ciprofloxacin resistant Escherichia coli strains are widely distributed. The phylogenetic backgrounds, antimicrobial resistance profiles, and virulence genes present in ciprofloxacin-resistant E. coli strains isolated from chickens and humans were evaluated in the study to identify their connection.Method: A total of 92 non-duplicate E. coli isolates collected between July 2020 to July 2021 from humans with urinary infections (n=57) and chickens with colibacillosis (n=35) were included in the study. Antimicrobial resistance of the isolates was determined using the disk diffusion method following EUCAST guidelines. Phylogroup, plasmid-mediated quinolone resistance genes, and virulent genes were identified using PCR.Results: Results revealed a high occurrence of ciprofloxacin resistance, with 65% of E coli isolates from urinary tract infections (UTI) in humans and 100% of chicken E. coli isolates showing resistance. Human strains showed significant co-resistance to third- and fourth-generation cephalosporins (p

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